首页> Proceedings of the National Academy of Sciences of the United States of America> Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and <i>N</i>-cadherin balance in mural cell-endothelial cell-regulated barrier function.

Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and <i>N</i>-cadherin balance in mural cell-endothelial cell-regulated barrier function.

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第一作者： Stella,Alimperti

第一单位： Department of Biomedical Engineering, Boston University, Boston, MA 02215.;Biological Design Center, Boston University, Boston, MA 02215.;The Wyss Institute for Biologically Inspired Engineering at Harvard, Harvard University, Boston, MA 02115.

作者： Stella,Alimperti ^[1] ; Teodelinda,Mirabella ^[1] ; Varnica,Bajaj ^[2] ; William,Polacheck ^[1] ; Dana M,Pirone ^[3] ; Jeremy,Duffield ^[4] ; Jeroen,Eyckmans ^[1] ; Richard K,Assoian ^[5] ; Christopher S,Chen ^[6]

作者单位： Department of Biomedical Engineering, Boston University, Boston, MA 02215.;Biological Design Center, Boston University, Boston, MA 02215.;The Wyss Institute for Biologically Inspired Engineering at Harvard, Harvard University, Boston, MA 02115. ^[1] Department of Biomedical Engineering, Boston University, Boston, MA 02215.;Biological Design Center, Boston University, Boston, MA 02215. ^[2] Department of Science, Mount St. Mary's University, Emmitsburg, MD 21727. ^[3] Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98195.;Department of Pathology, University of Washington, Seattle, WA 98195.;Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195. ^[4] Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104.;Program in Translational Biomechanics, Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104. ^[5] Department of Biomedical Engineering, Boston University, Boston, MA 02215; chencs@bu.edu.;Biological Design Center, Boston University, Boston, MA 02215.;The Wyss Institute for Biologically Inspired Engineering at Harvard, Harvard University, Boston, MA 02115. ^[6]

关键词 3D culture N-cadherin RhoGTPases mural cells vascular inflammation