The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.

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作者： Kelly M,Grimes ^[1] ; David Y,Barefield ^[2] ; Mohit,Kumar ^[3] ; James W,McNamara ^[4] ; Susan T,Weintraub ^[3] ; Pieter P,de Tombe ^[5] ; Sakthivel,Sadayappan ^[5] ; Rochelle,Buffenstein ^[6]

作者单位： Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ^[1] Sam and Ann Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ^[2] Department of Cell and Molecular Physiology, Health Sciences Division, Loyola University Chicago, Maywood, IL, USA. ^[3] Center for Genetic Medicine, Northwestern University, Chicago, IL, USA. ^[4] Heart, Lung and Vascular Institute, University of Cincinnati, Cincinnati, OH, USA. ^[5] Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ^[6] Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. rbuffen@calicolabs.com. ^[7] Sam and Ann Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. rbuffen@calicolabs.com. ^[8] Calico Life Sciences, 1170 Veterans Blvd, South San Francisco, CA, 94080, USA. rbuffen@calicolabs.com. ^[9]

关键词 Heart Hypoxia Naked mole-rat Neoteny Slow skeletal troponin I β myosin heavy chain