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Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.

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第一作者： Gulfem Dilek,Guler

第一单位： Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

作者： Gulfem Dilek,Guler ^[1] ; Charles Albert,Tindell ^[1] ; Robert,Pitti ^[1] ; Catherine,Wilson ^[1] ; Katrina,Nichols ^[2] ; Tommy,KaiWai Cheung ^[2] ; Hyo-Jin,Kim ^[1] ; Matthew,Wongchenko ^[3] ; Yibing,Yan ^[3] ; Benjamin,Haley ^[4] ; Trinna,Cuellar ^[4] ; Joshua,Webster ^[5] ; Navneet,Alag ^[1] ; Ganapati,Hegde ^[1] ; Erica,Jackson ^[1] ; Tracy Leah,Nance ^[6] ; Paul Garrett,Giresi ^[6] ; Kuan-Bei,Chen ^[7] ; Jinfeng,Liu ^[8] ; Suchit,Jhunjhunwala ^[8] ; Jeff,Settleman ^[1] ; Jean-Philippe,Stephan ^[2] ; David,Arnott ^[2] ; Marie,Classon ^[9]

作者单位： Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. ^[1] Protein Chemistry, Genentech Inc., South San Francisco, CA, USA. ^[2] LS Biomarker Development, Genentech Inc., South San Francisco, CA, USA. ^[3] Molecular Biology, Genentech Inc., South San Francisco, CA, USA. ^[4] Pathology, Genentech Inc., South San Francisco, CA, USA. ^[5] Epinomics, Menlo Park, CA, USA. ^[6] Active Motif, Carlsbad, CA, USA. ^[7] Bioinformatics, Genentech Inc., South San Francisco, CA, USA. ^[8] Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: classon.marie@gmail.com. ^[9]

关键词 ATRX G9a H3.3 H3K9-methylation HDACs HP1γ LINE-1 SETDB1 cancer cell heterogeneity chromatin