Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.

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第一作者： Takashi,Yamano

第一单位： Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

作者： Takashi,Yamano ^[1] ; Bernd,Zetsche ^[2] ; Ryuichiro,Ishitani ^[1] ; Feng,Zhang ^[2] ; Hiroshi,Nishimasu ^[3] ; Osamu,Nureki ^[4]

作者单位： Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[2] Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: nisimasu@bs.s.u-tokyo.ac.jp. ^[3] Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: nureki@bs.s.u-tokyo.ac.jp. ^[4]

关键词 CRISPR-Cas Cas12a Cpf1 crystal structure protospacer adjacent motif