Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

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作者： Lei,Cui ^[1] ; Sohyoung,Her ^[1] ; Gerben R,Borst ^[2] ; Robert G,Bristow ^[3] ; David A,Jaffray ^[4] ; Christine,Allen ^[5]

作者单位： Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada. ^[1] Department of Radiation Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. ^[2] Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada; Ontario Cancer Institute/Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. ^[3] Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; TECHNA Institute and Department of Radiation Physics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Physics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Techna Institute, University Health Network, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada. ^[4] Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada. Electronic address: cj.allen@utoronto.ca. ^[5]

关键词 5 Rs Gold nanoparticles Radiosensitizer Radiotherapy

主题词动物(Animals);金(Gold);人类(Humans);金属纳米粒子(Metal Nanoparticles);辐射耐受性(Radiation Tolerance);辐射增敏药(Radiation-Sensitizing Agents)

DOI 10.1016/j.radonc.2017.07.007

PMID 28784439

发布时间 2022-04-08

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