Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites.

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作者： Yan,Yan ^[1] ; Ting-Hai,Xu ^[2] ; Kaleeckal G,Harikumar ^[3] ; Laurence J,Miller ^[1] ; Karsten,Melcher ^[2] ; H Eric,Xu ^[3]

作者单位： From the Key Laboratory of Receptor Research, VARI-SIMM Center, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[1] the University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China. ^[2] the Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan 49503, and. ^[3] the Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259. ^[4] the Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan 49503, and Karsten.melcher@vai.org. ^[5] From the Key Laboratory of Receptor Research, VARI-SIMM Center, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China, eric.xu@vai.org. ^[6]

关键词 Alzheimer disease C99 FAD-linked mutations amyloid precursor protein (APP)amyloid-beta (AB)dimerization epsilon-cleavage assay transmembrane domain