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Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation.

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第一作者： Kohei,Kubota

第一单位： Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Sciences and Engineering, Waseda University (TWIns), Tokyo, Japan.;Formulation Research and Phramaceutical Process Group, CMC R&D Center, Kyowa Hakko Kirin Co., Ltd, Shizuoka, Japan.

作者： Kohei,Kubota ^[1] ; Kohei,Onishi ^[2] ; Kazuaki,Sawaki ^[2] ; Tianshu,Li ^[3] ; Kaoru,Mitsuoka ^[4] ; Takaaki,Sato ^[5] ; Shinji,Takeoka ^[6]

作者单位： Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Sciences and Engineering, Waseda University (TWIns), Tokyo, Japan.;Formulation Research and Phramaceutical Process Group, CMC R&D Center, Kyowa Hakko Kirin Co., Ltd, Shizuoka, Japan. ^[1] Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering,Waseda University (TWIns), Tokyo, Japan. ^[2] Research Organization for Nano and Life Innovation, Waseda University (TWIns), Tokyo, Japan. ^[3] Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, Osaka, Japan. ^[4] Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, Nagano, Japan. ^[5] Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Sciences and Engineering, Waseda University (TWIns), Tokyo, Japan.;Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering,Waseda University (TWIns), Tokyo, Japan.;Research Organization for Nano and Life Innovation, Waseda University (TWIns), Tokyo, Japan. ^[6]

关键词 confocal microscopy cryo-TEM endocytosis immune stimulation nanoformulation siRNA