Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export.

导出 OA

翻译打印收藏纠错

作者： Jing,Fan ^[1] ; Bin,Kuai ^[1] ; Guifen,Wu ^[1] ; Xudong,Wu ^[2] ; Binkai,Chi ^[1] ; Lantian,Wang ^[1] ; Ke,Wang ^[1] ; Zhubing,Shi ^[1] ; Heng,Zhang ^[1] ; She,Chen ^[3] ; Zhisong,He ^[4] ; Siyuan,Wang ^[1] ; Zhaocai,Zhou ^[1] ; Guohui,Li ^[5] ; Hong,Cheng ^[6]

作者单位： State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. ^[1] Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. ^[2] National Institute of Biological Sciences, Beijing, China. ^[3] CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. ^[4] Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China ghli@dicp.ac.cn hcheng@sibcb.ac.cn. ^[5] State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China ghli@dicp.ac.cn hcheng@sibcb.ac.cn. ^[6]

关键词 ALYREF ARS2 hMTR4 mRNA export nuclear RNA degradation