Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis.

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作者： Jérôme,Avouac ^[1] ; Christophe,Guignabert ^[2] ; Anna Maria,Hoffmann-Vold ^[3] ; Barbara,Ruiz ^[4] ; Peter,Dorfmuller ^[2] ; Sonia,Pezet ^[4] ; Olivia,Amar ^[4] ; Ly,Tu ^[2] ; Jérôme,Van Wassenhove ^[4] ; Jérémy,Sadoine ^[5] ; David,Launay ^[6] ; Muriel,Elhai ^[1] ; Anne,Cauvet ^[4] ; Arun,Subramaniam ^[7] ; Robert,Resnick ^[7] ; Eric,Hachulla ^[6] ; Øyvind,Molberg ^[3] ; André,Kahan ^[8] ; Marc,Humbert ^[9] ; Yannick,Allanore ^[1]

作者单位： Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016 and CNRS UMR8104, Institut Cochin, and Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France. ^[1] Inserm, UMR S 999, Plessis Robinson, France, and Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France. ^[2] Oslo University Hospital-Rikshospitalet and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[3] Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016 and CNRS UMR8104, Institut Cochin, Paris, France. ^[4] EA 2496 Pathologie, Imagerie et Biothérapies Orofaciales, UFR Odontologie, Université Paris Descartes and PIDV, PRES Sorbonne Paris Cité, Montrouge, France. ^[5] Médecine Interne, Hopital Huriez, Université de Lille, Lille, France. ^[6] Sanofi Genzyme, Framingham, Massachusetts. ^[7] Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France. ^[8] Inserm UMR S 999, Plessis Robinson, France, and Université Paris-Sud, Université Paris-Saclay and AP-HP, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France. ^[9]

主题词成年人(Adult);老年人(Aged);动物(Animals);抗体, 中和(Antibodies, Neutralizing);病例对照研究(Case-Control Studies);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);疾病模型, 动物(Disease Models, Animal);内皮细胞(Endothelial Cells);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);女(雌)性(Female);Fos相关抗原2(Fos-Related Antigen-2);人类(Humans);高血压, 肺性(Hypertension, Pulmonary);肺(Lung);男(雄)性(Male);基质金属蛋白酶10(Matrix Metalloproteinase 10);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);微阵列分析(Microarray Analysis);中年人(Middle Aged);血小板源性生长因子(Platelet-Derived Growth Factor);肺动脉(Pulmonary Artery);肺纤维化(Pulmonary Fibrosis);硬皮病, 系统性(Scleroderma, Systemic);信号传导(Signal Transduction)

DOI 10.1002/art.40229

PMID 28805015

发布时间 2018-01-19

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Arthritis & rheumatology (Hoboken, N.J.)

2017年69卷11期

2209-2221页

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Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis.

Arthritis & rheumatology (Hoboken, N.J.)

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Arthritis & rheumatology (Hoboken, N.J.)

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Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis.

Arthritis & rheumatology (Hoboken, N.J.)

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Arthritis & rheumatology (Hoboken, N.J.)

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