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Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

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第一作者： Jesper,Pallesen

第一单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.

作者： Jesper,Pallesen ^[1] ; Nianshuang,Wang ^[2] ; Kizzmekia S,Corbett ^[3] ; Daniel,Wrapp ^[4] ; Robert N,Kirchdoerfer ^[1] ; Hannah L,Turner ^[1] ; Christopher A,Cottrell ^[1] ; Michelle M,Becker ^[5] ; Lingshu,Wang ^[6] ; Wei,Shi ^[6] ; Wing-Pui,Kong ^[6] ; Erica L,Andres ^[5] ; Arminja N,Kettenbach ^[7] ; Mark R,Denison ^[8] ; James D,Chappell ^[5] ; Barney S,Graham ^[3] ; Andrew B,Ward ^[9] ; Jason S,McLellan ^[2]

作者单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037. ^[1] Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755; Nianshuang.Wang@dartmouth.edu andrew@scripps.edu Jason.S.McLellan@Dartmouth.edu. ^[2] Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. ^[3] Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755. ^[4] Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232. ^[5] Virology Core, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. ^[6] Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.;Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756. ^[7] Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232.;Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232. ^[8] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037; Nianshuang.Wang@dartmouth.edu andrew@scripps.edu Jason.S.McLellan@Dartmouth.edu. ^[9]

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