首页> mSphere> Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in <i>Candida albicans</i>.

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in <i>Candida albicans</i>.

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第一作者： Tobias,Weil

第一单位： Department of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal.;Research and Innovation Centre, Fondazione E. Mach, San Michele All'Adige, Italy.

作者： Tobias,Weil ^[1] ; Rodrigo,Santamaría ^[2] ; Wanseon,Lee ^[3] ; Johan,Rung ^[4] ; Noemi,Tocci ^[5] ; Darren,Abbey ^[6] ; Ana R,Bezerra ^[7] ; Laura,Carreto ^[7] ; Gabriela R,Moura ^[7] ; Mónica,Bayés ^[8] ; Ivo G,Gut ^[8] ; Attila,Csikasz-Nagy ^[9] ; Duccio,Cavalieri ^[5] ; Judith,Berman ^[10] ; Manuel A S,Santos ^[7]

作者单位： Department of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal.;Research and Innovation Centre, Fondazione E. Mach, San Michele All'Adige, Italy. ^[1] Department of Computer Science, University of Salamanca, Salamanca, Spain. ^[2] European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.;Wellcome Trust Centre for Human Genetics, University of Oxford, Roosvelt Drive, Oxford, United Kingdom. ^[3] European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.;SciLifeLab, Uppsala University, Uppsala, Sweden. ^[4] Research and Innovation Centre, Fondazione E. Mach, San Michele All'Adige, Italy. ^[5] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA. ^[6] Department of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. ^[7] Centro Nacional de Análisis Genómico, Parc Científic, Barcelona, Spain. ^[8] Research and Innovation Centre, Fondazione E. Mach, San Michele All'Adige, Italy.;Randall Division of Cell and Molecular Biophysics and Institute for Mathematical and Molecular Biomedicine, King's College London, London, United Kingdom. ^[9] Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel. ^[10]

关键词 Candida albicans LOH aneuploidy codon ambiguity drug resistance evolution fluconazole phenotypic variability protein mistranslation

DOI 10.1128/mSphere.00167-17

PMID 28808688

发布时间 2019-11-20

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Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in <i>Candida albicans</i>.

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Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in <i>Candida albicans</i>.

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