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Escape of Tick-Borne Flavivirus from 2'-<i>C</i>-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness.

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第一作者: Ludek,Eyer
第一单位: Department of Virology, Veterinary Research Institute, Brno, Czech Republic.;Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
作者单位: Department of Virology, Veterinary Research Institute, Brno, Czech Republic.;Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic. [1] Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. [2] Department of Virology, Veterinary Research Institute, Brno, Czech Republic. [3] Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan. [4] Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.;Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. [5] Central Laboratories, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. [6] Institute for Medical Microbiology, Otto von Guericke University Magdeburg, Magdeburg, Germany. [7] Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany. [8] Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic. [9] Rega Institute for Medical Research, KU Leuven, Leuven, Belgium. [10] Department of Virology, Veterinary Research Institute, Brno, Czech Republic ruzekd@paru.cas.cz.;Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic. [11]
DOI 10.1128/JVI.01028-17
PMID 28814513
发布时间 2019-11-20
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