首页> Leukemia> Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

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第一作者： S,Gerboth

第一单位： Department of Molecular Oncology, IFOM Foundation, Institute FIRC of Molecular Oncology, Milan, Italy.

作者： S,Gerboth ^[1] ; E,Frittoli ^[1] ; A,Palamidessi ^[1] ; F C,Baltanas ^[2] ; M,Salek ^[1] ; J,Rappsilber ^[1] ; C,Giuliani ^[1] ; F,Troglio ^[1] ; Y,Rolland ^[1] ; G,Pruneri ^[3] ; S,Kreutmair ^[4] ; I,Pallavicini ^[3] ; M,Zobel ^[1] ; M,Cinquanta ^[5] ; S,Minucci ^[6] ; C,Gomez ^[2] ; E,Santos ^[2] ; A L,Illert ^[7] ; G,Scita ^[8]

作者单位： Department of Molecular Oncology, IFOM Foundation, Institute FIRC of Molecular Oncology, Milan, Italy. ^[1] Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CSIC-Universidad de Salamanca) and CIBERONC, Salamanca, Spain. ^[2] European Institute of Oncology, Milano, Italy. ^[3] Department of Biosciences, University of Milan, Milan, Italy. ^[4] Cogentech S.c.a.r.l., at IFOM Via Adamello, Milan, Italy. ^[5] European Institute of Oncology, Milano, Italy.;Department of Biosciences, University of Milan, Milan, Italy. ^[6] Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany.;German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[7] Department of Molecular Oncology, IFOM Foundation, Institute FIRC of Molecular Oncology, Milan, Italy.;Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. ^[8]