Covalent coupling of high-affinity ligands to the surface of viral vector particles by protein trans-splicing mediates cell type-specific gene transfer.
第一作者:
Alexander,Muik
第一单位:
Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225, Langen, Germany.
作者:
主题词
动物(Animals);CHO细胞(CHO Cells);细胞系, 肿瘤(Cell Line, Tumor);仓鼠属(Cricetulus);依赖病毒(Dependovirus);基因转移技术(Gene Transfer Techniques);遗传载体(Genetic Vectors);HEK293细胞(HEK293 Cells);人类(Humans);内含肽类(Inteins);配体(Ligands);反式剪接(Trans-Splicing);转导, 遗传(Transduction, Genetic);病毒粒子(Virion)
DOI
10.1016/j.biomaterials.2017.07.032
PMID
28825979
发布时间
2018-05-15
- 浏览46
Biomaterials
84-94页
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