Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

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作者： Hanna,Tarhonskaya ^[1] ; Radosław P,Nowak ^[2] ; Catrine,Johansson ^[3] ; Aleksandra,Szykowska ^[2] ; Anthony,Tumber ^[2] ; Rebecca L,Hancock ^[1] ; Pauline,Lang ^[1] ; Emily,Flashman ^[1] ; Udo,Oppermann ^[4] ; Christopher J,Schofield ^[5] ; Akane,Kawamura ^[6]

作者单位： Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom. ^[1] Structural Genomic Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. ^[2] Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom; Botnar Research Centre, NIHR Oxford Biomedical Research Unit, University of Oxford, Windmill Road, Oxford, OX3 7LD, United Kingdom. ^[3] Structural Genomic Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom; Botnar Research Centre, NIHR Oxford Biomedical Research Unit, University of Oxford, Windmill Road, Oxford, OX3 7LD, United Kingdom. ^[4] Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom. Electronic address: christopher.schofield@chem.ox.ac.uk. ^[5] Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom. Electronic address: akane.kawamura@chem.ox.ac.uk. ^[6]

关键词 2-oxoglutarate oxygenase KDM5B TCA cycle inhibition epigenetics lysine JmjC demethylase