Fragment analysis represents a suitable approach for the detection of hotspot c.7541_7542delCT NOTCH1 mutation in chronic lymphocytic leukemia.

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第一作者： Eva,Vavrova

第一单位： Central European Institute of Technology (CEITEC) and Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic.

作者： Eva,Vavrova ^[1] ; Barbara,Kantorova ^[2] ; Barbara,Vonkova ^[1] ; Jitka,Kabathova ^[3] ; Hana,Skuhrova-Francova ^[3] ; Eva,Diviskova ^[3] ; Ondrej,Letocha ^[3] ; Jana,Kotaskova ^[2] ; Yvona,Brychtova ^[3] ; Michael,Doubek ^[2] ; Jiri,Mayer ^[2] ; Sarka,Pospisilova ^[4]

作者单位： Central European Institute of Technology (CEITEC) and Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic. ^[1] Central European Institute of Technology (CEITEC) and Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Cernopolni 9, CZ-613 00 Brno, Czech Republic. ^[2] Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Cernopolni 9, CZ-613 00 Brno, Czech Republic. ^[3] Central European Institute of Technology (CEITEC) and Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Cernopolni 9, CZ-613 00 Brno, Czech Republic. Electronic address: sarka.pospisilova@ceitec.muni.cz. ^[4]

关键词 Allele-specific PCR CLL Fragment analysis NOTCH1 mutation Sequencing

主题词 DNA突变分析(DNA Mutational Analysis);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);白血病, 淋巴细胞, 慢性, B细胞(Leukemia, Lymphocytic, Chronic, B-Cell);突变(Mutation);肽碎片(Peptide Fragments);受体, Notch1(Receptor, Notch1)

DOI 10.1016/j.leukres.2017.08.001

PMID 28837890

发布时间 2018-05-01

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