CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.-论文-万方医学网

第一作者： Yongqing,Liu

第一单位： Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.

作者： Yongqing,Liu ^[1] ; Shirong,Lai ^[2] ; Weining,Ma ^[1] ; Wei,Ke ^[2] ; Chan,Zhang ^[3] ; Shumeng,Liu ^[4] ; Yu,Zhang ^[5] ; Fei,Pei ^[1] ; Shaoyi,Li ^[1] ; Ming,Yi ^[6] ; Yousheng,Shu ^[3] ; Yongfeng,Shang ^[5] ; Jing,Liang ^[4] ; Zhuo,Huang ^[1]

作者单位： Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. ^[1] Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China. ^[2] Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110000, China. ^[3] State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, School of Brain and Cognitive Sciences, the Collaborative Innovation Center for Brain Science, Beijing Normal University, Beijing, 100875, China. ^[4] Neuroscience Research Institute & Department of Neurobiology, Peking University Health Science Center, Beijing, 100191, China. ^[5] Department of Pathology, Peking University Health Science Center, Beijing, 100191, China. ^[6] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. ^[7] Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, 300070, China. ^[8] Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. liang_jing@bjmu.edu.cn. ^[9] Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. huangz@hsc.pku.edu.cn. ^[10] Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China. huangz@hsc.pku.edu.cn. ^[11] State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China. huangz@hsc.pku.edu.cn. ^[12]

主题词动物(Animals);辅阻遏蛋白质类(Co-Repressor Proteins);癫痫(Epilepsy);基因表达调控(Gene Expression Regulation);基因敲低技术(Gene Knockdown Techniques);海马(Hippocampus);组蛋白酰基转移酶(Histone Acetyltransferases);人类(Humans);氢裂合酶类(Hydro-Lyases);离子通道闸门(Ion Channel Gating);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);神经元可塑性(Neuronal Plasticity);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);发作(Seizures)

DOI 10.1038/s41467-017-00368-z

PMID 28842554

发布时间 2020-12-09

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CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.

Nature communications

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CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.

Nature communications

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Nature communications

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