换一批
换一批Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma.
第一作者：
Janice K,Laramy
第一单位：
Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (J.K.L., M.K., K.E.P., S.Z., W.F.E.) and Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (S.K.G., K.K.B., B.L.C., A.C.M., D.J.M., J.N.S.).
作者：
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);脑(Brain);脑肿瘤(Brain Neoplasms);细胞存活(Cell Survival);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);胶质母细胞瘤(Glioblastoma);HEK293细胞(HEK293 Cells);人类(Humans);咪唑类(Imidazoles);男(雄)性(Male);小鼠(Mice);小鼠, 裸(Mice, Nude);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);哒嗪类(Pyridazines);随机分配(Random Allocation);治疗结果(Treatment Outcome);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1124/jpet.117.243477
PMID
28847917
发布时间
2025-03-06
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