Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma.-论文-万方医学网

作者： Janice K,Laramy ^[1] ; Minjee,Kim ^[1] ; Shiv K,Gupta ^[1] ; Karen E,Parrish ^[1] ; Shuangling,Zhang ^[1] ; Katrina K,Bakken ^[1] ; Brett L,Carlson ^[1] ; Ann C,Mladek ^[1] ; Daniel J,Ma ^[1] ; Jann N,Sarkaria ^[1] ; William F,Elmquist ^[2]

作者单位： Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (J.K.L., M.K., K.E.P., S.Z., W.F.E.) and Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (S.K.G., K.K.B., B.L.C., A.C.M., D.J.M., J.N.S.). ^[1] Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (J.K.L., M.K., K.E.P., S.Z., W.F.E.) and Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (S.K.G., K.K.B., B.L.C., A.C.M., D.J.M., J.N.S.) elmqu011@umn.edu. ^[2]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);脑(Brain);脑肿瘤(Brain Neoplasms);细胞存活(Cell Survival);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);胶质母细胞瘤(Glioblastoma);HEK293细胞(HEK293 Cells);人类(Humans);咪唑类(Imidazoles);男(雄)性(Male);小鼠(Mice);小鼠, 裸(Mice, Nude);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);哒嗪类(Pyridazines);随机分配(Random Allocation);治疗结果(Treatment Outcome);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1124/jpet.117.243477

PMID 28847917

发布时间 2019-01-27

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Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma.

The Journal of pharmacology and experimental therapeutics

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The Journal of pharmacology and experimental therapeutics

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Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma.

The Journal of pharmacology and experimental therapeutics

相似文献

The Journal of pharmacology and experimental therapeutics

相关期刊

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