The transcription factor Gbx2 induces expression of Kruppel-like factor 4 to maintain and induce naïve pluripotency of embryonic stem cells.

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作者： Manman,Wang ^[1] ; Ling,Tang ^[1] ; Dahai,Liu ^[1] ; Qi-Long,Ying ^[2] ; Shoudong,Ye ^[3]

作者单位： From the Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei 230601, China and. ^[1] the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033. ^[2] From the Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei 230601, China and shdye@126.com. ^[3]

关键词 Gbx2 Kruppel-like factor 4 (KLF4)cell biology differentiation embryonic stem cell reprogramming self-renewal

主题词动物(Animals);细胞系(Cell Line);基因敲低技术(Gene Knockdown Techniques);同源盒结构域蛋白质类(Homeodomain Proteins);Kruppel样转录因子类(Kruppel-Like Transcription Factors);小鼠(Mice)

DOI 10.1074/jbc.M117.803254

PMID 28848051

发布时间 2021-12-04

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