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PTEN allelic loss is an important mechanism in the late stage of development of oral leucoplakia into oral squamous cell carcinoma.

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第一作者： Ligia A N,Miyahara

第一单位： Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.

作者： Ligia A N,Miyahara ^[1] ; Flávia S C,Pontes ^[2] ; Rommel M R,Burbano ^[2] ; Nicolau,Conte Neto ^[2] ; Douglas M,Guimarães ^[2] ; Felipe P,Fonseca ^[3] ; Hélder A R,Pontes ^[4]

作者单位： Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil. ^[1] João de Barros, Barreto University Hospital (HUJBB), Federal University of Pará (UFPA), Pará, Brazil. ^[2] Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais (UFMG), Minas Gerais, Brazil. ^[3] Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil.;João de Barros, Barreto University Hospital (HUJBB), Federal University of Pará (UFPA), Pará, Brazil. ^[4]

关键词 PTEN phosphatase gene deletion immunohistochemistry leucoplakia oral cancer