Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.

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第一作者： Gang,Liu

第一单位： Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.

作者： Gang,Liu ^[1] ; Marion A,Cooley ^[2] ; Prema M,Nair ^[1] ; Chantal,Donovan ^[1] ; Alan C,Hsu ^[1] ; Andrew G,Jarnicki ^[3] ; Tatt Jhong,Haw ^[1] ; Nicole G,Hansbro ^[1] ; Qi,Ge ^[4] ; Alexandra C,Brown ^[1] ; Hock,Tay ^[1] ; Paul S,Foster ^[1] ; Peter A,Wark ^[5] ; Jay C,Horvat ^[1] ; Jane E,Bourke ^[6] ; Chris L,Grainge ^[1] ; W Scott,Argraves ^[2] ; Brian G,Oliver ^[7] ; Darryl A,Knight ^[1] ; Janette K,Burgess ^[8] ; Philip M,Hansbro ^[1]

作者单位： Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia. ^[1] Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA. ^[2] Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.;Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia. ^[3] Woolcock Institute of Medical Research, Discipline of Pharmacology, University of Sydney, Sydney, New South Wales, Australia. ^[4] Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.;Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia. ^[5] Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Parkville, Victoria, Australia. ^[6] Woolcock Institute of Medical Research, Discipline of Pharmacology, University of Sydney, Sydney, New South Wales, Australia.;School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia. ^[7] Woolcock Institute of Medical Research, Discipline of Pharmacology, University of Sydney, Sydney, New South Wales, Australia.;University of Groningen, University Medical Centre Groningen, Department of Pathology and Medical Biology, Groningen Research Institute of Asthma and COPD, Groningen, The Netherlands. ^[8]

关键词 airway hyperresponsiveness airway remodelling allergic airway disease asthma collagen fibrosis fibulin-1 inflammation lung function