Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.

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作者： Kevin B,Dagbay ^[1] ; Jeanne A,Hardy ^[2]

作者单位： Department of Chemistry, University of Massachusetts, Amherst, MA 01002. ^[1] Department of Chemistry, University of Massachusetts, Amherst, MA 01002 hardy@chem.umass.edu. ^[2]

关键词 apoptosis conformational dynamics cysteine protease hydrogen exchange MS neurodegeneration

主题词半胱氨酸天冬氨酸蛋白酶6(Caspase 6);氘交换测定(Deuterium Exchange Measurement);人类(Humans);分子动力学模拟(Molecular Dynamics Simulation);蛋白质结构, 二级(Protein Structure, Secondary)

DOI 10.1073/pnas.1704640114

PMID 28864531

发布时间 2018-11-13

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Proceedings of the National Academy of Sciences of the United States of America

2017年114卷38期

E7977-E7986页

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Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.

Proceedings of the National Academy of Sciences of the United States of America

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Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.

Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

相关期刊

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