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首页> European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V> Enhanced transmucosal delivery of itraconazole by thiolated d-ɑ-tocopheryl poly(ethylene glycol) 1000 succinate micelles for the treatment of Candida albicans.

Enhanced transmucosal delivery of itraconazole by thiolated d-ɑ-tocopheryl poly(ethylene glycol) 1000 succinate micelles for the treatment of Candida albicans.

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作者： Jiraphong,Suksiriworapong ^[1] ; Thawanrat,Mingkwan ^[2] ; Doungdaw,Chantasart ^[3]

作者单位： Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand; Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. ^[1] Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. ^[2] Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand; Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. Electronic address: doungdaw.cha@mahidol.ac.th. ^[3]

关键词 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (PubChem CID:2723939)5,5′-dithiobis(2-nitrobenzoic acid) (PubChem CID:6254)Candida albicans Itraconazole Itraconazole (PubChem CID:55283)Micelles Mucoadhesive Pyrene (PubChem CID:31423)Succinic anhydride (PubChem CID:7922)TPGS (PubChem CID: 71406)Thiolated polymer Transmucosal delivery d-ɑ-tocopheryl polyethylene glycol 1000 succinate l-cysteine hydrochloride (PubChem CID:60960)

主题词抗真菌药(Antifungal Agents);白色念珠菌(Candida albicans);念珠菌病(Candidiasis);人类(Humans);伊曲康唑(Itraconazole);微胶粒(Micelles);口腔黏膜(Mouth Mucosa);纳米粒子(Nanoparticles);聚合物(Polymers);维生素E(Vitamin E)

DOI 10.1016/j.ejpb.2017.08.012

PMID 28865759

发布时间 2018-05-31

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European journal of pharmaceutics and biopharmaceutics

107-115页

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