Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses.

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作者： Chris,Lauber ^[1] ; Stefan,Seitz ^[2] ; Simone,Mattei ^[3] ; Alexander,Suh ^[4] ; Jürgen,Beck ^[5] ; Jennifer,Herstein ^[6] ; Jacob,Börold ^[7] ; Walter,Salzburger ^[8] ; Lars,Kaderali ^[9] ; John A G,Briggs ^[3] ; Ralf,Bartenschlager ^[10]

作者单位： Institute for Medical Informatics and Biometry, Technische Universität Dresden, 01307 Dresden, Germany. ^[1] University of Heidelberg, Department of Infectious Diseases, Molecular Virology, 69120 Heidelberg, Germany. Electronic address: stefan.seitz@med.uni-heidelberg.de. ^[2] Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. ^[3] Department of Evolutionary Biology, Evolutionary Biology Centre (EBC), Uppsala University, 75236 Uppsala, Sweden. ^[4] Department of Internal Medicine 2/Molecular Biology, University Hospital Freiburg, 79106 Freiburg, Germany. ^[5] Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. ^[6] University of Heidelberg, Department of Infectious Diseases, Molecular Virology, 69120 Heidelberg, Germany. ^[7] Zoological Institute, University of Basel, 4051 Basel, Switzerland. ^[8] Institute for Medical Informatics and Biometry, Technische Universität Dresden, 01307 Dresden, Germany; Institute for Bioinformatics, University Medicine Greifswald, 17487 Greifswald, Germany. ^[9] University of Heidelberg, Department of Infectious Diseases, Molecular Virology, 69120 Heidelberg, Germany; Division of Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. ^[10]

关键词 hepadnaviruses hepatitis B virus overlapping open reading frames viral gene evolution virus discovery virus origins virus-host long-term co-evolution