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Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib.

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第一作者： Kazuhiro,Yamamoto

第一单位： Department of Pharmacy, Kobe University Hospital.

作者： Kazuhiro,Yamamoto ^[1] ; Hiroaki,Shichiri ^[2] ; Takahiro,Ishida ^[3] ; Kenta,Kaku ^[2] ; Tatsuya,Nishioka ^[1] ; Manabu,Kume ^[1] ; Hiroo,Makimoto ^[1] ; Tsutomu,Nakagawa ^[4] ; Takeshi,Hirano ^[5] ; Toshinori,Bito ^[6] ; Chikako,Nishigori ^[6] ; Ikuko,Yano ^[4] ; Midori,Hirai ^[2]

作者单位： Department of Pharmacy, Kobe University Hospital. ^[1] Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine. ^[2] R&D Department, Momotani Juntenkan Ltd. ^[3] Department of Pharmacy, Kobe University Hospital.;Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine. ^[4] Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine.;Graduate School of Pharmaceutical Sciences, Health Sciences University of Hokkaido. ^[5] Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine. ^[6]

关键词 ascorbic acid hand–foot skin reaction (HFSR)multi-targeted tyrosine kinase inhibitor vitamin C