Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.-论文-万方医学网

作者： Min,Liu ^[1] ; Kaili,Liang ^[1] ; Junhui,Zhen ^[2] ; Meng,Zhou ^[1] ; Xiaojie,Wang ^[1] ; Ziying,Wang ^[1] ; Xinbing,Wei ^[1] ; Yan,Zhang ^[1] ; Yu,Sun ^[1] ; Zhuanli,Zhou ^[3] ; Hua,Su ^[3] ; Chun,Zhang ^[3] ; Ningjun,Li ^[4] ; Chengjiang,Gao ^[5] ; Jun,Peng ^[6] ; Fan,Yi ^[7]

作者单位： Department of Pharmacology, Shandong University School of Medicine, Jinan, 250012, China. ^[1] Department of Pathology, Shandong University School of Medicine, Jinan, 250012, China. ^[2] Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ^[3] Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA. ^[4] Department of Immunology, Shandong University School of Medicine, Jinan, 250012, China. ^[5] Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, China. ^[6] Department of Pharmacology, Shandong University School of Medicine, Jinan, 250012, China. fanyi@sdu.edu.cn. ^[7]

主题词乙酰化作用(Acetylation);动物(Animals);细胞凋亡(Apoptosis);自噬(Autophagy);活组织检查(Biopsy);糖尿病, 实验性(Diabetes Mellitus, Experimental);糖尿病肾病(Diabetic Nephropathies);减量调节(Down-Regulation);多柔比星(Doxorubicin);基因缺失(Gene Deletion);组蛋白类(Histones);人类(Humans);炎症(Inflammation);整合酶类(Integrases);肾(Kidney);赖氨酸(Lysine);男(雄)性(Male);小鼠, 基因敲除(Mice, Knockout);足细胞(Podocytes);启动区, 遗传(Promoter Regions, Genetic);蛋白尿(Proteinuria);大鼠(Rats);受体, Notch(Receptors, Notch);信号传导(Signal Transduction);抗衰老酶(Sirtuins)

DOI 10.1038/s41467-017-00498-4

PMID 28871079

发布时间 2018-11-13

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Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Nature communications

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Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Nature communications

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Nature communications

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