Identification of HSP90 inhibitors as a novel class of senolytics.-论文-万方医学网

第一作者： Heike,Fuhrmann-Stroissnigg

第一单位： Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA.

作者： Heike,Fuhrmann-Stroissnigg ^[1] ; Yuan Yuan,Ling ^[1] ; Jing,Zhao ^[1] ; Sara J,McGowan ^[1] ; Yi,Zhu ^[2] ; Robert W,Brooks ^[1] ; Diego,Grassi ^[1] ; Siobhan Q,Gregg ^[3] ; Jennifer L,Stripay ^[3] ; Akaitz,Dorronsoro ^[1] ; Lana,Corbo ^[1] ; Priscilla,Tang ^[1] ; Christina,Bukata ^[1] ; Nadja,Ring ^[4] ; Mauro,Giacca ^[4] ; Xuesen,Li ^[1] ; Tamara,Tchkonia ^[2] ; James L,Kirkland ^[2] ; Laura J,Niedernhofer ^[1] ; Paul D,Robbins ^[5]

作者单位： Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA. ^[1] University of Pittsburgh School of Medicine, Pittsburgh, 15261, PA, USA. ^[2] Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, 55905, MN, USA. ^[3] International Centre for Genetic Engineering and Biotechnology, Trieste, 34100, Italy. ^[4] Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA. probbins@scripps.edu. ^[5]

主题词衰老(Aging);动物(Animals);细胞凋亡(Apoptosis);自噬(Autophagy);苯醌类(Benzoquinones);生物学鉴定法(Biological Assay);DNA结合蛋白质类(DNA-Binding Proteins);减量调节(Down-Regulation);药物评价, 临床前(Drug Evaluation, Preclinical);内切核酸酶类(Endonucleases);女(雌)性(Female);成纤维细胞(Fibroblasts);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);内酰胺类, 大环(Lactams, Macrocyclic);小鼠(Mice);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);信号传导(Signal Transduction);小分子化合物库(Small Molecule Libraries)

DOI 10.1038/s41467-017-00314-z

PMID 28871086

发布时间 2024-09-22

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Identification of HSP90 inhibitors as a novel class of senolytics.

Nature communications

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Identification of HSP90 inhibitors as a novel class of senolytics.

Nature communications

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Nature communications

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