Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.

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作者： Erik H,Klontz ^[1] ; Adam D,Tomich ^[2] ; Sebastian,Günther ^[3] ; Justin A,Lemkul ^[1] ; Daniel,Deredge ^[4] ; Zach,Silverstein ^[5] ; JoAnna F,Shaw ^[5] ; Christi,McElheny ^[1] ; Yohei,Doi ^[3] ; Patrick L,Wintrode ^[3] ; Alexander D,MacKerell ^[3] ; Nicolas,Sluis-Cremer ^[6] ; Eric J,Sundberg ^[5]

作者单位： Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA. ^[1] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. ^[2] Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. ^[3] University of Maryland Computer-Aided Drug Design Center, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. ^[4] Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. ^[5] Center for Innovative Antimicrobial Therapy, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. ^[6] Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA esundberg@ihv.umaryland.edu. ^[7] Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA. ^[8]

关键词 Escherichia coli FosA FosA3 FosAKP FosAPA Klebsiella X-ray crystallography fosfomycin