Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease.-论文-万方医学网

作者： Jun,Ikari ^[1] ; Amy J,Nelson ^[2] ; Jannah,Obaid ^[1] ; Alvaro,Giron-Martinez ^[1] ; Kumiko,Ikari ^[1] ; Fumihiko,Makino ^[1] ; Shunichiro,Iwasawa ^[1] ; Yoko,Gunji ^[1] ; Maha,Farid ^[1] ; Xingqi,Wang ^[1] ; Hesham,Basma ^[1] ; Dawn,Demeo ^[1] ; Carol,Feghali-Bostwick ^[3] ; Olaf,Holz ^[4] ; Klaus,Rabe ^[5] ; Xiangde,Liu ^[6] ; Stephen I,Rennard ^[1]

作者单位： Pulmonary, Critical Care, Sleep and Allergy Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America. ^[1] Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan. ^[2] Channing Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America. ^[3] Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America. ^[4] Fraunhofer ITEM, Member of the German Center for Lung Research (DZL, BREATH), Hannover, Germany. ^[5] Airway Research Center North (ARCN), Lungen Clinic Grosshansdorf, Member of the German Center for Lung Research, Grosshansdorf, Germany. ^[6]

主题词 3'非翻译区(3' Untranslated Regions);成年人(Adult);碱基序列(Base Sequence);病例对照研究(Case-Control Studies);细胞, 培养的(Cells, Cultured);慢性病(Chronic Disease);地诺前列酮(Dinoprostone);细胞外基质(Extracellular Matrix);女(雌)性(Female);成纤维细胞(Fibroblasts);纤连蛋白类(Fibronectins);基因表达调控(Gene Expression Regulation);人类(Humans);白细胞介素1β(Interleukin-1beta);白细胞介素8(Interleukin-8);肺(Lung);男(雄)性(Male);微RNAs(MicroRNAs);中年人(Middle Aged);蛋白质结合(Protein Binding);肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);RNA, 信使(RNA, Messenger);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);血管内皮生长因子A(Vascular Endothelial Growth Factor A)

DOI 10.1371/journal.pone.0184039

PMID 28880936

发布时间 2022-03-17

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Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease.

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Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease.

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