Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis.

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作者： Sugong,Chen ^[1] ; Robert C,Fisher ^[1] ; Steven,Signs ^[2] ; L Alex,Molina ^[2] ; Anitha K,Shenoy ^[2] ; Maria-Cecilia,Lopez ^[3] ; Henry V,Baker ^[3] ; John M,Koomen ^[3] ; Yi,Chen ^[4] ; Haley,Gittleman ^[4] ; Jill,Barnholtz-Sloan ^[5] ; Annamarie,Berg ^[5] ; Henry D,Appelman ^[2] ; Emina H,Huang ^[6]

作者单位： Department of Surgery, University of Florida, Gainesville, Florida 32610, USA. ^[1] Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA. ^[2] Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 32610, USA. ^[3] Molecular Oncology and Proteomics, SRB3, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA. ^[4] Bioinformatics, Case Comprehensive Cancer Center, Cleveland, Ohio 44106, USA. ^[5] Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. ^[6]

关键词 ALDEFLUOR PI3K/Akt/mTOR signaling apoptosis colon cancer stem cells tumorigenesis

DOI 10.18632/oncotarget.9919

PMID 28881576

发布时间 2018-11-13

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