The anti-ErbB2 antibody H2-18 and the pan-PI3K inhibitor GDC-0941 effectively inhibit trastuzumab-resistant ErbB2-overexpressing breast cancer.

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第一作者： Lingfei,Wang

第一单位： Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.

作者： Lingfei,Wang ^[1] ; Xiaojie,Yu ^[2] ; Chao,Wang ^[2] ; Shujun,Pan ^[2] ; Beibei,Liang ^[3] ; Yajun,Zhang ^[1] ; Xiaodan,Chong ^[2] ; Yanchun,Meng ^[2] ; Jian,Dong ^[4] ; Yirong,Zhao ^[5] ; Yang,Yang ^[2] ; Huajing,Wang ^[2] ; Jie,Gao ^[2] ; Huafeng,Wei ^[6] ; Jian,Zhao ^[1] ; Hao,Wang ^[2] ; Chaohua,Hu ^[1] ; Wenze,Xiao ^[2] ; Bohua,Li ^[2]

作者单位： Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China. ^[1] International Joint Cancer Institute, Second Military Medical University, Shanghai 200433, China. ^[2] Hangzhou Sanatorium of People's Liberation Army, Hangzhou 310007, China. ^[3] Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China. ^[4] Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. ^[5] Department of Pharmaceutical Sciences, Second Military Medical University, Shanghai 200433, China. ^[6] Department of General Surgery, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 432000, China. ^[7] Department of Rheumatology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China. ^[8]

关键词 GDC-0941 anti-ErbB2 antibody breast cancer programmed cell death trastuzumab resistance

DOI 10.18632/oncotarget.17907

PMID 28881779

发布时间 2018-11-13

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