Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

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第一作者： Marianna,Hösel

第一单位： Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

作者： Marianna,Hösel ^[1] ; Maria,Quasdorff ^[2] ; Marc,Ringelhan ^[3] ; Hamid,Kashkar ^[4] ; Svenja,Debey-Pascher ^[5] ; Martin F,Sprinzl ^[6] ; Jan-Hendrik,Bockmann ^[7] ; Silke,Arzberger ^[8] ; Dennis,Webb ^[1] ; Gesa,von Olshausen ^[9] ; Achim,Weber ^[10] ; Joachim L,Schultze ^[5] ; Hildegard,Büning ^[11] ; Mathias,Heikenwalder ^[12] ; Ulrike,Protzer ^[7]

作者单位： Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. ^[1] Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.;Department of Gastroenterology and Hepatology, University Hospital of Cologne, Cologne, Germany. ^[2] Institute of Virology, Technische Universität München / Helmholtz Zentrum München, Munich, Germany.;Department of Internal Medicine II, University Hospital of the Technical University of Munich, Munich, Germany. ^[3] Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.;Institute of Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, Cologne, Germany. ^[4] Institute for Life and Medical Sciences, Genomics and Immunoregulation, University of Bonn, Bonn, Germany. ^[5] Institute of Virology, Technische Universität München / Helmholtz Zentrum München, Munich, Germany.;1 Medical Department, University Hospital Mainz, Mainz, Germany. ^[6] Institute of Virology, Technische Universität München / Helmholtz Zentrum München, Munich, Germany.;German Centre for Infection Research, Partner sites Bonn-Cologne, Hannover-Braunschweig, Hamburg, and Munich, Germany. ^[7] Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.;Institute of Virology, Technische Universität München / Helmholtz Zentrum München, Munich, Germany. ^[8] Department of Internal Medicine I, University Hospital of the Technical University of Munich, Munich, Germany. ^[9] Institute of Surgical Pathology, University Hospital Zürich, Zürich, Switzerland. ^[10] Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.;German Centre for Infection Research, Partner sites Bonn-Cologne, Hannover-Braunschweig, Hamburg, and Munich, Germany.;Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany. ^[11] Institute of Virology, Technische Universität München / Helmholtz Zentrum München, Munich, Germany.;German Centre for Infection Research, Partner sites Bonn-Cologne, Hannover-Braunschweig, Hamburg, and Munich, Germany.;Department Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany. ^[12]

关键词 APR, acute phase response Apoptosis CRP, C-reactive protein DMSO, dimethyl sulfoxide FCS, fetal calf serum HBV pg RNA, hepatitis B pregenomic RNA HBV, Hepatitis B virus HBVtg, hepatitis B transgenic HBeAg, hepatitis B early antigen HCC, hepatocellular carcinoma HNF, hepatocyte nuclear factor Hepatitis B Virus Infection Hepatocellular Carcinoma IFN, interferon IL-6, interleukin 6 IRF3, interferon regulatory factor 3 NAC, N-acetyl-L-cysteine PCR, polymerase chain reaction PHH, primary human hepatocyte ROS, reactive oxygen species RT, reverse transcription STAT3 Signaling STAT3, signal transducer and activator of transcription 3 cDNA, complementary DNA cRNA, complementary RNA cccDNA, covalently closed circular DNA mRNA, messenger RNA p.i., postinfection pSTAT3, phosphorylated signal transducer and activator of transcription 3 pgRNA, pregenomic RNA siRNA, small interfering RNA

DOI 10.1016/j.jcmgh.2017.07.003

PMID 28884137

发布时间 2019-11-20

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Cellular and molecular gastroenterology and hepatology

2017年4卷3期

339-363页

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Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Cellular and molecular gastroenterology and hepatology

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Cellular and molecular gastroenterology and hepatology

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Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Cellular and molecular gastroenterology and hepatology

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Cellular and molecular gastroenterology and hepatology

相关期刊

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