Development, validation, and clinical pharmacokinetic application of ultra-performance liquid chromatography/tandem mass spectrometry method for simultaneously determining a novel recombinant hirudin derivative (Neorudin) and its active metabolite in human serum.

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第一作者： Xiaona,Dong

第一单位： State Key Laboratory of Drug Metabolism and Pharmacokinetics, Laboratory of Hematological Pharmacology, Beijing Institute of Transfusion Medicine, 27, Taiping Road, Haidian District, Beijing 100850, PR China. Electronic address: dxn2004386@sina.com.

作者： Xiaona,Dong ^[1] ; Zhiyun,Meng ^[2] ; Jide,Jin ^[3] ; Ruolan,Gu ^[4] ; Guifang,Dou ^[5]

作者单位： State Key Laboratory of Drug Metabolism and Pharmacokinetics, Laboratory of Hematological Pharmacology, Beijing Institute of Transfusion Medicine, 27, Taiping Road, Haidian District, Beijing 100850, PR China. Electronic address: dxn2004386@sina.com. ^[1] State Key Laboratory of Drug Metabolism and Pharmacokinetics, Laboratory of Hematological Pharmacology, Beijing Institute of Transfusion Medicine, 27, Taiping Road, Haidian District, Beijing 100850, PR China. Electronic address: mengzhiyun@vip.163.com. ^[2] Laboratory of Experimental Hematology, Beijing Institute of Radiation Medicine, 27, Taiping Road, Beijing 100850, PR China. Electronic address: jinjide505@163.com. ^[3] State Key Laboratory of Drug Metabolism and Pharmacokinetics, Laboratory of Hematological Pharmacology, Beijing Institute of Transfusion Medicine, 27, Taiping Road, Haidian District, Beijing 100850, PR China. Electronic address: gurl311@126.com. ^[4] State Key Laboratory of Drug Metabolism and Pharmacokinetics, Laboratory of Hematological Pharmacology, Beijing Institute of Transfusion Medicine, 27, Taiping Road, Haidian District, Beijing 100850, PR China. Electronic address: douguifang@vip.163.com. ^[5]

关键词 Anticoagulant fusion protein Hirudin variant 2-Lys47 Human serum Pharmacokinetics Recombinant neorudin UPLC–MS/MS

主题词色谱法, 高压液相(Chromatography, High Pressure Liquid);水蛭素类(Hirudins);人类(Humans);线性模型(Linear Models);重组蛋白质类(Recombinant Proteins);结果可重复性(Reproducibility of Results);敏感性与特异性(Sensitivity and Specificity);串联质谱法(Tandem Mass Spectrometry)

DOI 10.1016/j.jchromb.2017.08.030

PMID 28886579

发布时间 2017-10-02

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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2017年1063卷

204-213页

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Development, validation, and clinical pharmacokinetic application of ultra-performance liquid chromatography/tandem mass spectrometry method for simultaneously determining a novel recombinant hirudin derivative (Neorudin) and its active metabolite in human serum.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

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Development, validation, and clinical pharmacokinetic application of ultra-performance liquid chromatography/tandem mass spectrometry method for simultaneously determining a novel recombinant hirudin derivative (Neorudin) and its active metabolite in human serum.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

相似文献

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

相关期刊

检索历史清除