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首页> Matrix biology : journal of the International Society for Matrix Biology> Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.

Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.

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作者： Shyam K,Bandari ^[1] ; Anurag,Purushothaman ^[1] ; Vishnu C,Ramani ^[1] ; Garrett J,Brinkley ^[1] ; Darshan S,Chandrashekar ^[1] ; Sooryanarayana,Varambally ^[1] ; James A,Mobley ^[2] ; Yi,Zhang ^[3] ; Elizabeth E,Brown ^[1] ; Israel,Vlodavsky ^[4] ; Ralph D,Sanderson ^[5]

作者单位： University of Alabama at Birmingham, Department of Pathology, Birmingham, 35294, USA. ^[1] University of Alabama at Birmingham, Department of Surgery, Birmingham, 35294, USA. ^[2] Eli Lilly and Company, New York, 10016, USA. ^[3] Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel. ^[4] University of Alabama at Birmingham, Department of Pathology, Birmingham, 35294, USA. Electronic address: ralphsanderson@uabmc.edu. ^[5]

关键词 Chemoexosome Chemotherapy Exosome Heparanase Macrophage Myeloma

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物疗法(Drug Therapy);外泌体(Exosomes);细胞外基质(Extracellular Matrix);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);葡糖醛酸糖苷酶(Glucuronidase);人类(Humans);美法仑(Melphalan);小鼠(Mice);多发性骨髓瘤(Multiple Myeloma);寡肽类(Oligopeptides);信号传导(Signal Transduction);增量调节(Up-Regulation)

DOI 10.1016/j.matbio.2017.09.001

PMID 28888912

发布时间 2021-12-01

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