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mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis.

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第一作者： Chloë,Scheldeman

第一单位： Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium.

作者： Chloë,Scheldeman ^[1] ; James D,Mills ^[2] ; Aleksandra,Siekierska ^[1] ; Ines,Serra ^[3] ; Daniëlle,Copmans ^[1] ; Anand M,Iyer ^[2] ; Benjamin J,Whalley ^[4] ; Jan,Maes ^[1] ; Anna C,Jansen ^[5] ; Lieven,Lagae ^[6] ; Eleonora,Aronica ^[7] ; Peter A M,de Witte ^[8]

作者单位： Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium. ^[1] Department of (Neuro) Pathology, Academic Medical Center and Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, Stichting Epilepsie Instellingen Nederland (SEIN), The Netherlands. ^[2] School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK. ^[3] Reading School of Pharmacy, University of Reading, Reading, Berkshire RG6 6UB, UK. ^[4] Pediatric Neurology Unit, UZ Brussel, Neurogenetics research group, VUB, Brussels, Belgium. ^[5] Department of Paediatric Neurology, University Hospitals Leuven, Leuven, Belgium. ^[6] Department of (Neuro) Pathology, Academic Medical Center and Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, Stichting Epilepsie Instellingen Nederland (SEIN), The Netherlands. Electronic address: e.aronica@amc.uva.nl. ^[7] Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium. Electronic address: peter.dewitte@kuleuven.be. ^[8]

关键词 Transcriptomics Tuberous sclerosis complex Zebrafish mTOR