Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA.

导出 OA

翻译打印收藏纠错

第一作者： Ian Mitchelle S,de Vera

第一单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.

作者： Ian Mitchelle S,de Vera ^[1] ; Jie,Zheng ^[2] ; Scott,Novick ^[2] ; Jinsai,Shang ^[1] ; Travis S,Hughes ^[1] ; Richard,Brust ^[1] ; Paola,Munoz-Tello ^[1] ; William J,Gardner ^[3] ; David P,Marciano ^[2] ; Xiangming,Kong ^[1] ; Patrick R,Griffin ^[2] ; Douglas J,Kojetin ^[4]

作者单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. ^[1] Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. ^[2] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; TSRI High School Student Summer Internship Program, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. ^[3] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. Electronic address: dkojetin@scripps.edu. ^[4]

关键词 NMR spectroscopy allostery cooperativity hydrogen/deuterium exchange (HDX) mass spectrometry ligand binding nuclear receptor peroxisome proliferator-activated receptor retinoid X receptor stabilization transcription