CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone.

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作者： Antonio G Gomes,de Mello Martins ^[1] ; Giuseppe,Allegretta ^[1] ; Gerhard,Unteregger ^[2] ; Jörg,Haupenthal ^[1] ; Jens,Eberhard ^[1] ; Michael,Hoffmann ^[3] ; Jill A,van der Zee ^[2] ; Kerstin,Junker ^[2] ; Michael,Stöckle ^[2] ; Rolf,Müller ^[3] ; Rolf W,Hartmann ^[4] ; Carsten-H,Ohlmann ^[5]

作者单位： Department of Drug Design and Optimization (DDOP), Helmholtz Institute for Pharmaceutical Research Saarland, Campus E8.1, 66123 Saarbrücken, Germany. ^[1] Saarland University, Department of Urology and Pediatric Urology, 66424 Homburg/Saar, Germany. ^[2] Department of Microbial Natural Products (MINS), Helmholtz Institute for Pharmaceutical Research Saarland, Campus E8.1, 66123 Saarbrücken, Germany. ^[3] Department of Drug Design and Optimization (DDOP), Helmholtz Institute for Pharmaceutical Research Saarland, Campus E8.1, 66123 Saarbrücken, Germany; Department of Pharmaceutical and Medicinal Chemistry, Saarland University, 66123 Saarbrücken, Germany. Electronic address: Rolf.Hartmann@helmholtz-hzi.de. ^[4] Saarland University, Department of Urology and Pediatric Urology, 66424 Homburg/Saar, Germany. Electronic address: Carsten.Ohlmann@uks.eu. ^[5]

关键词 4-Abiraterone 5-pregnan-3,6-diol-20-one CYP17A1 Castration-resistant prostate cancer Neuroendocrine differentiation Neurosteroid Steroidogenesis