Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat.

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作者： Jennifer L,Dumouchel ^[1] ; Upendra A,Argikar ^[1] ; Jaimie,Spear ^[2] ; Ann,Brown ^[1] ; Christine E,Dunne ^[3] ; Valerie M,Kramlinger ^[1] ; Amanda L,Cirello ^[4] ; Mithat,Gunduz ^[1]

作者单位： Analytical Sciences and Imaging, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA. ^[1] Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA. ^[2] Department of Chemistry, Colorado State University, Fort Collins, CO, USA. ^[3] Present affiliation: Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., Cambridge, MA, USA. ^[4] Present affiliation: Tarveda Therapeutics, Watertown, MA, USA. ^[5]

关键词 N-acetyltransferase Ocular metabolism bioactivation cytochrome P450 first pass metabolism β-adrenergic antagonists

主题词肾上腺素能β受体拮抗剂(Adrenergic beta-Antagonists);动物(Animals);芳基烃羟化酶类(Aryl Hydrocarbon Hydroxylases);酶测定(Enzyme Assays);眼(Eye);青光眼, 开角型(Glaucoma, Open-Angle);眼内压(Intraocular Pressure);肝(Liver);男(雄)性(Male);模型, 动物(Models, Animal);眼药水(Ophthalmic Solutions);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);噻吗洛尔(Timolol)

DOI 10.2174/1872312811666170911122919

PMID 28891437

发布时间 2018-10-22

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Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat.

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Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat.

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