Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice.

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作者： Derek R,Stein ^[1] ; Joseph W,Golden ^[2] ; Bryan D,Griffin ^[3] ; Bryce M,Warner ^[3] ; Charlene,Ranadheera ^[1] ; Leanne,Scharikow ^[1] ; Angela,Sloan ^[1] ; Kathy L,Frost ^[1] ; Darwyn,Kobasa ^[3] ; Stephanie A,Booth ^[3] ; Matthew,Josleyn ^[2] ; John,Ballantyne ^[4] ; Eddie,Sullivan ^[5] ; Jin-An,Jiao ^[5] ; Hua,Wu ^[5] ; Zhongde,Wang ^[6] ; Jay W,Hooper ^[2] ; David,Safronetz ^[3]

作者单位： Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada. ^[1] Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA. ^[2] Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada. ^[3] Aldevron, Fargo, ND, USA. ^[4] SAB Biotherapeutics, Sioux Falls, SD, USA. ^[5] Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA. ^[6]

关键词 Human polyclonal antibody Testicular atrophy Trans-chromosomal bovine Zika