Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.
第一作者:
Shanshan,Zhu
第一单位:
Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287.;Department of Psychiatry, JHU SOM, Baltimore, MD 21287.
作者:
医学主题词
动物(Animals);锚蛋白类(Ankyrins);双相情感障碍(Bipolar Disorder);疾病模型, 动物(Disease Models, Animal);锂(Lithium);哌醋甲酯(Methylphenidate);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);钾通道, 电压门控(Potassium Channels, Voltage-Gated);前脑(Prosencephalon);原癌基因蛋白质c-fyn(Proto-Oncogene Proteins c-fyn);突触(Synapses);丙戊酸(Valproic Acid)
DOI
10.1073/pnas.1700689114
PMID
28894008
发布时间
2026-05-15
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