首页> European journal of pharmacology> Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization.

Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization.

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第一作者： Alba,Iglesias

第一单位： BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avenida de Barcelona 22, 15782 Santiago de Compostela, Spain.

作者： Alba,Iglesias ^[1] ; Marta,Cimadevila ^[1] ; Rocío Ailim de,la Fuente ^[2] ; María,Martí-Solano ^[3] ; María Isabel,Cadavid ^[1] ; Marián,Castro ^[2] ; Jana,Selent ^[3] ; María Isabel,Loza ^[4] ; José,Brea ^[5]

作者单位： BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avenida de Barcelona 22, 15782 Santiago de Compostela, Spain. ^[1] BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avenida de Barcelona 22, 15782 Santiago de Compostela, Spain; Molecular Pharmacology of G Protein-coupled Receptors Laboratory, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avenida de Barcelona 22, 15782 Santiago de Compostela, Spain. ^[2] GPCR Drug Discovery Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Department of Experimental and Health Sciences of Pompeu Fabra University (UPF), Barcelona, Spain. ^[3] BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avenida de Barcelona 22, 15782 Santiago de Compostela, Spain. Electronic address: mabel.loza@usc.es. ^[4] BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avenida de Barcelona 22, 15782 Santiago de Compostela, Spain. Electronic address: pepo.brea@usc.es. ^[5]

关键词 Clozapine (PubChem CID: 2818)DL-1,4-Dithiothreitol (PubChem CID: 446094)Disulfide bridges Dithiothreitol Methysergide maleate (PubChem CID: 5281073)Phospholipase A(2)Phospholipase C Radioligand binding Serotonin 2(A) receptor Serotonin hydrochloride (PubChem CID: 160436)[(3)H]LSD (PubChem CID: 44559100)