Antidepressants inhibit Nav1.3, Nav1.7, and Nav1.8 neuronal voltage-gated sodium channels more potently than Nav1.2 and Nav1.6 channels expressed in Xenopus oocytes.

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作者： Takafumi,Horishita ^[1] ; Nobuyuki,Yanagihara ^[2] ; Susumu,Ueno ^[3] ; Dan,Okura ^[4] ; Reiko,Horishita ^[4] ; Tomoko,Minami ^[4] ; Yuichi,Ogata ^[4] ; Yuka,Sudo ^[5] ; Yasuhito,Uezono ^[6] ; Takeyoshi,Sata ^[4] ; Takashi,Kawasaki ^[4]

作者单位： Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka, 807-8555, Japan. thori@med.uoeh-u.ac.jp. ^[1] Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka, 807-8555, Japan. ^[2] Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka, 807-8555, Japan. ^[3] Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka, 807-8555, Japan. ^[4] Department of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. ^[5] Cancer Pathophysiology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuouku, Tokyo, 104-0045, Japan. ^[6]

关键词 Dorsal root ganglion Duloxetine Tricyclic antidepressants Voltage-gated sodium channels