An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[<sup>18</sup>F]Fluorobenzyl-Triphenylphosphonium ([<sup>18</sup>F]FBnTP).

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作者： Christopher M,Waldmann ^[1] ; Adrian,Gomez ^[2] ; Phillip,Marchis ^[1] ; Sean T,Bailey ^[3] ; Milica,Momcilovic ^[3] ; Anthony E,Jones ^[1] ; David B,Shackelford ^[3] ; Saman,Sadeghi ^[4]

作者单位： Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA, 90095, USA. ^[1] Department of Chemistry and Biochemistry, University of California Los Angeles, 607 Charles E Young Dr. S, Los Angeles, CA, 90095, USA. ^[2] Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. ^[3] Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA, 90095, USA. samsadeghi@mednet.ucla.edu. ^[4]

关键词 4-[18F]Fluorobenzyl-triphenylphosphonium 4-[18F]fluorobenzaldehyde Antioxidants Mitochondrial metabolism Positron emission tomography Radiolysis Solid-phase extraction purification [18F]FBnTP

主题词自动化(Automation);分子探针(Molecular Probes);有机磷化合物(Organophosphorus Compounds);正电子发射断层显像术(Positron-Emission Tomography);电位测定法(Potentiometry)

DOI 10.1007/s11307-017-1119-1

PMID 28905308

发布时间 2019-08-28

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