Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.

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第一作者： Frank,Raven

第一单位： Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA; Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen 9747 AG, The Netherlands.

作者： Frank,Raven ^[1] ; Joseph F,Ward ^[2] ; Katarzyna M,Zoltowska ^[3] ; Yu,Wan ^[4] ; Enjana,Bylykbashi ^[2] ; Sean J,Miller ^[2] ; Xunuo,Shen ^[2] ; Se Hoon,Choi ^[2] ; Kevin D,Rynearson ^[5] ; Oksana,Berezovska ^[3] ; Steven L,Wagner ^[6] ; Rudolph E,Tanzi ^[7] ; Can,Zhang ^[8]

作者单位： Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA; Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen 9747 AG, The Netherlands. ^[1] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA. ^[2] Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA. ^[3] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, PR China. ^[4] Department of Neurosciences, University of California, La Jolla, San Diego, CA 92093-0624, USA. ^[5] Department of Neurosciences, University of California, La Jolla, San Diego, CA 92093-0624, USA; Research Biologist, VA San Diego Healthcare System, La Jolla, CA, 92161, United States. Electronic address: slwagner@ucsd.edu. ^[6] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA. Electronic address: tanzi@helix.mgh.harvard.edu. ^[7] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA. Electronic address: zhang.can@mgh.harvard.edu. ^[8]

关键词 Alzheimer's disease Notch β-amyloid β-amyloid precursor protein γ-secretase γ-secretase modulator

主题词别构部位(Allosteric Site);阿尔茨海默病(Alzheimer Disease);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);CHO细胞(CHO Cells);细胞, 培养的(Cells, Cultured);仓鼠属(Cricetulus);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);人类(Humans);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);神经元(Neurons);早老素1(Presenilin-1);蛋白质构象(Protein Conformation)

DOI 10.1016/j.ebiom.2017.08.028

PMID 28919280

发布时间 2019-10-08

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2017年24卷

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Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.

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Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.

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