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首页> The Journal of clinical investigation> Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.

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作者： Chunhua,Dai ^[1] ; Yan,Hang ^[2] ; Alena,Shostak ^[1] ; Greg,Poffenberger ^[1] ; Nathaniel,Hart ^[1] ; Nripesh,Prasad ^[3] ; Neil,Phillips ^[1] ; Shawn E,Levy ^[3] ; Dale L,Greiner ^[4] ; Leonard D,Shultz ^[5] ; Rita,Bottino ^[6] ; Seung K,Kim ^[2] ; Alvin C,Powers ^[7]

作者单位： Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. ^[1] Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA. ^[2] Hudson Alpha Institute for Biotechnology, Huntsville, Alabama, USA. ^[3] Department of Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA. ^[4] The Jackson Laboratory, Bar Harbor, Maine, USA. ^[5] Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, Pennsylvania, USA. ^[6] Department of Medicine, Stanford University School of Medicine, Stanford California, USA. ^[7] Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. ^[8] VA Tennessee Valley Healthcare System, Nashville, Tennessee, USA. ^[9]

主题词成年人(Adult);衰老(Aging);动物(Animals);钙神经素(Calcineurin);细胞周期蛋白A1(Cyclin A1);女(雌)性(Female);胰高血糖素样肽1(Glucagon-Like Peptide 1);人类(Humans);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);男(雄)性(Male);小鼠, 近交NOD(Mice, Inbred NOD);中年人(Middle Aged);NFATC转录因子类(NFATC Transcription Factors);肽类(Peptides);信号传导(Signal Transduction);毒液类(Venoms)

DOI 10.1172/JCI91761

PMID 28920919

发布时间 2022-04-09

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The Journal of clinical investigation

The Journal of clinical investigation

2017年127卷10期

3835-3844页

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