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The N<sup>6</sup>-methyladenosine (m<sup>6</sup>A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.

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作者单位: Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [1] Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York, USA. [2] Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, New York, USA. [3] Hematologic Oncology Tissue Bank, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [4] Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [5] Memorial Sloan Kettering Cancer Center, Department of Medicine, Leukemia Service, New York, New York, USA. [6] Department of Medicine and Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA. [7] Division of Hematology and Medical Oncology, Department of Medicine and Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York, USA. [8] Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [9] The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York, USA. [10] The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA. [11]
DOI 10.1038/nm.4416
PMID 28920958
发布时间 2024-06-10
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