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Evaluation of intensity drift correction strategies using MetaboDrift, a normalization tool for multi-batch metabolomics data.

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第一作者： Chanisa,Thonusin

第一单位： Department of Internal Medicine, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States; Department of Molecular and Integrative Physiology, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States; Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

作者： Chanisa,Thonusin ^[1] ; Heidi B,IglayReger ^[2] ; Tanu,Soni ^[2] ; Amy E,Rothberg ^[2] ; Charles F,Burant ^[3] ; Charles R,Evans ^[4]

作者单位： Department of Internal Medicine, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States; Department of Molecular and Integrative Physiology, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States; Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. ^[1] Department of Internal Medicine, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States. ^[2] Department of Internal Medicine, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States; Department of Molecular and Integrative Physiology, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States. ^[3] Department of Internal Medicine, University of Michigan, 6300 Brehm Tower, 1000 Wall St., Ann Arbor, MI 48109, United States. Electronic address: chevans@umich.edu. ^[4]

关键词 Drift correction Intensity drift LC–MS Meal tolerance test Metabolomics Normalization

医学主题词色谱法, 液相(Chromatography, Liquid);人类(Humans);质谱分析法(Mass Spectrometry);代谢组学(Metabolomics);软件(Software)

DOI 10.1016/j.chroma.2017.09.023

PMID 28927937

发布时间 2019-12-10

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准确一般字义偏差语意偏离译文作用小提交