Impact of Experimental Variables on the Protein Binding of Tigecycline in Human Plasma as Determined by Ultrafiltration.

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第一作者： Christoph,Dorn

第一单位： Department of Clinical Pharmacy, University of Regensburg, Regensburg, Germany. Electronic address: christoph.dorn@ur.de.

作者： Christoph,Dorn ^[1] ; Alexander,Kratzer ^[2] ; Uwe,Liebchen ^[3] ; Michael,Schleibinger ^[3] ; Alexandra,Murschhauser ^[4] ; Jens,Schlossmann ^[4] ; Frieder,Kees ^[4] ; Philipp,Simon ^[5] ; Martin G,Kees ^[6]

作者单位： Department of Clinical Pharmacy, University of Regensburg, Regensburg, Germany. Electronic address: christoph.dorn@ur.de. ^[1] Hospital Pharmacy, University Hospital Regensburg, Regensburg, Germany. ^[2] Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany. ^[3] Department of Pharmacology, University of Regensburg, Regensburg, Germany. ^[4] Department of Anesthesia and Intensive Care Medicine, University of Leipzig, Leipzig, Germany. ^[5] Department of Anesthesiology, University Hospital Regensburg, Regensburg, Germany. ^[6]

关键词 HPLC (high-performance/pressure liquid chromatography)albumin antiinfectives bioanalysis calcium chelation pH patients tetracycline unbound fraction

主题词血蛋白质类(Blood Proteins);人类(Humans);米诺环素(Minocycline);血浆(Plasma);蛋白质结合(Protein Binding);超滤(Ultrafiltration)

DOI 10.1016/j.xphs.2017.09.006

PMID 28927988

发布时间 2018-12-02

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