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Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.

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作者单位: Ludwig Institute for Cancer Research, Department of Fundamental Oncology, University of Lausanne, Biopole 3-02DB61, Ch. Des Boveresses 155, CH-1066, Epalinges, Switzerland. sara.trabanelli@gmail.com. [1] Urology Research Unit, Lausanne University Hospital (CHUV), 1011, Lausanne, Switzerland. [2] Ludwig Institute for Cancer Research, Department of Fundamental Oncology, University of Lausanne, Biopole 3-02DB61, Ch. Des Boveresses 155, CH-1066, Epalinges, Switzerland. [3] Department of Specialistic, Diagnostic and Experimental Medicine, Institute of Hematology "Seràgnoli", University of Bologna, 40138, Bologna, Italy. [4] Swiss Institute of Bioinformatics (SIB), 1015, Lausanne, Switzerland. [5] Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 7270, Davos, Switzerland. [6] Christine Kühne-Center for Allergy Research and Education, 7265, Davos, Switzerland. [7] Department of Medical Biotechnologies and Translational Medicine, University of Milan, 20133, Milan, Italy. [8] Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, 20089, Rozzano-Milan, Italy. [9] Department of Experimental Oncology, European Institute of Oncology, 20139, Milan, Italy. [10] Department of Hematology, Bern University Hospital, University of Bern, 3010, Bern, Switzerland. [11] Humanitas Cancer Center, Humanitas Clinical and Research Center, 20089, Rozzano-Milan, Italy. [12] Department of Biomedical Sciences, Humanitas University, 20089, Rozzano-Milan, Italy. [13] Hematology and Bone Marrow Transplant Unit, Ospedale Papa Giovanni XXIII, 24127, Bergamo, Italy. [14] Università Statale di Milano, 20122, Milan, Italy. [15] Dipartimento per la Salute della Donna e del Bambino, Clinica di Oncoematologia Pediatrica, University of Padova, 35128, Padova, Italy. [16] Immunoematologia e Medicina Trasfusionale, Laboratorio Ematologia Molecolare, Biobanca Neoplasie Ematologiche, San Raffaele Hospital, 20132, Milano, Italy. [17] Divisione di Ricerca di Medicina Rigenerativa, Terapia Cellulare e Genica IRCCS, San Raffaele Hospital, 20132, Milano, Italy. [18] Division of Innovative Therapies, European Institute of Oncology, 20141, Milan, Italy. [19] Department of Experimental Medicine (DI.ME.S.)-Section of Histology, and Center of Excellent of Biomedical Research (CEBR), University of Genoa, 16132, Genoa, Italy. [20] MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. [21] Ludwig Institute for Cancer Research, Department of Fundamental Oncology, University of Lausanne, Biopole 3-02DB61, Ch. Des Boveresses 155, CH-1066, Epalinges, Switzerland. camilla.jandus@chuv.ch. [22]
DOI 10.1038/s41467-017-00678-2
PMID 28928446
发布时间 2022-01-29
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