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Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus.

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第一作者： Sophie,Hackinger

第一单位： Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK.

作者： Sophie,Hackinger ^[1] ; Katerina,Trajanoska ^[2] ; Unnur,Styrkarsdottir ^[3] ; Eleni,Zengini ^[4] ; Julia,Steinberg ^[1] ; Graham R S,Ritchie ^[1] ; Konstantinos,Hatzikotoulas ^[1] ; Arthur,Gilly ^[1] ; Evangelos,Evangelou ^[5] ; John P,Kemp ^[6] ; arcOGEN Consortium, GEFOS Consortium ^[6] ; David,Evans ^[7] ; Thorvaldur,Ingvarsson ^[8] ; Helgi,Jonsson ^[9] ; Unnur,Thorsteinsdottir ^[9] ; Kari,Stefansson ^[10] ; Andrew W,McCaskie ^[10] ; Roger A,Brooks ^[11] ; Jeremy M,Wilkinson ^[2] ; Fernando,Rivadeneira ^[1] ; Eleftheria,Zeggini

作者单位： Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK. ^[1] Departments of Internal Medicine and Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands. ^[2] deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland. ^[3] Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.;5th Department, Dromokaiteio Psychiatric Hospital, Athens 124 61, Greece. ^[4] Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece.;Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. ^[5] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia. ^[6] Department of Orthopedic Surgery, Akureyri Hospital, 600 Akureyri, Iceland.;Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.;Institution of Health Science, University of Akureyri, 600 Akureyri, Iceland. ^[7] Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.;Department of Medicine, Landspitali, The National University Hospital of Iceland, 101 Reykjavik, Iceland. ^[8] deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.;Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland. ^[9] Division of Trauma & Orthopaedic Surgery, University of Cambridge, Box 180, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. ^[10] Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK. ^[11]